The duration of therapy depends on the type and incidence of fungal infections.
Usually there are adverse reactions following: fever (sometimes with fantastic chills), nausea and vomiting, generalized pain, pain in the place of intravenous (phlebitis) and violations of renal function (gipokaliemiya, increase the level of serum creatinine and residual nitrogen, the velocity of creatinine clearance, lower concentrating kidney function). Prior appointment antipiretikov can reduce the feverish reaction. To reduce the feverish and other fatal reactions can be added to the solution hydrocortisone. Over time, there is tolerance to feverish reactions, allowing lower dose of hydrocortisone, and then abandon it. Some analysts added to a solution of heparin to prevent flebita. More severe reactions are rare anuria, oliguriya, anemia and other hematologic deviations gipomagneziemiya, toxic defeat cardiovascular function (arrhythmia, hypertension, hypotension), anafilaktoidnye reactions, convulsions and other neurological symptoms. Patients with fungal infections of the central nervous system with no effect on intravenous drug should be preferred simultaneous introduction of amphotericin B intratekalno, intraventrikulyarno and intratsisternalno. Injections preferably done in the lateral ventricles, through tsisternalny tank Omayya. The role of such an approach clearly established only if koktsidionalnom meningitis, but it can be justified from the unsuccessful treatment of patients with other fungal infections, when the concentration of drug in the cerebrospinal fluid is low or not is determined after the intravenous drug. Amphotericin B can be applied twice a week or more intralyumbalno, intratsisternalno or intraventrikulyarno. The normal starting dose of 0025 mg. Subsequent doses increased by doubling up to the maintenance dose 0,1-0,5 mg. The solution should be fresh, divorced in 2-10 ml of sterile 5% by the aqueous dextrose (10% dextrose in water for injection endolyumbalnyh) without preservatives. Before the injection solution before the introduction of divorces sinnomozgovoy liquid, so that the final concentration of 1 ml of 0.1 doses. The duration of therapy depends on the clinical and mikologicheskogo results. As required to produce crops cerebrospinal fluid on the fungi and bacteria. As a result intratekalnoy therapy experienced nausea, vomiting, a delay of urine, pain in his legs and back, headache, tranzitornye radiculitis, disorders of sensitivity and otvisshaya foot, also met various permanent violations.