Modifications of the recommendations may depend on the individual assessment of disease, changes in renal function and other factors affecting the pharmacokinetics, reaction of the patient and laboratory data. In such cases, to avoid toxicity and confirm the therapeutic efficacy recommended dynamic definition of drugs in serum. It should be guided and annotation attached to the package, to clarify the details of preparing injectable drugs, measures to avoid incompatibility and other precautions.
In some cases, drugs are recommended for specific reasons, different from the Commission on food and medicines and specified in the annotations. This does not preclude the possibility of a doctor of medicine, but to prevent the misuse of adequate medical evidence, discretion and caution.
Modern medical practice permits the use of drugs in situations that are not reflected in the attached annotations. The decision on the appointment of medicine is justified by a physician, who must take into account the risks and benefits of the drug, regardless of the available estimate.